UNIVERSITY OF GUAM

COURSE OUTLINE

COURSE NUMBER: CH 420 COLLEGE(OR SPONSORING UNIT): CAS/NATURAL SCIENCES

COURSE TITLE: Nuclear Magnetic Resonance Spectroscopy CREDIT HOURS: 3

DATE OF FINAL APPROVAL: ____________________ SEMESTER OFFERED: Fall

Course counts as General Education Requirement

Ö Part of Chemistry major program

Ö Elective (upper division)

in Chemistry and Physical Science

1. CATALOG DESCRIPTION:

Principles and applications of NMR spectroscopy, utilizing examples from organic, inorganic, and biological chemistry will be covered. The course will involve three hours of classroom study per week.

Prerequisites: CH31O a-b, CH312, MA204 and consent of instructor.

2. COURSE CONTENT:

Topics covered will include the theory of Nuclear Magnetic Resonance, instrumentation and techniques, chemical shifts, spin-spin and dipolar interactions, relaxation, analysis of complex spectra, structure elucidation, chemical exchange and dynamic NMR, two-dimensional NMR and selected contemporary developments in NMR Spectroscopy; may also include electron paramagnetic resonance spectroscopy.

3. RATIONALE FOR THE COURSE:

NMR Spectroscopy is one of the most powerful research tools currently used in chemistry. This course aims to provides a comprehensive view of basic nuclear magnetic resonance principles and applications. This course will provide a strong foundation in NMR for students planning to pursue graduate studies in chemistry, biochemistry and medicine.

4. SKILLS AND BACKGROUND REQUIRED OR EXPECTED:

A sound knowledge of sophomore level (one-year) organic chemistry and integral calculus will be required.

5. TEACHING METHODOLOGIES AND ANTICIPATED CLASS SIZE:

Lectures and discussion sessions, problem-solving sessions and computer methods of data analysis will be employed. The anticipated class size is about eight students.

6. ADDITIONAL COURSE DESCRIPTORS:

None

7. LEARNING OBJECTIVES FOR STUDENTS:

The student will

· Demonstrate a sound knowledge of principles of pulsed Fourier transform methods, instrumentation and techniques.

· Analyze complex NMR spectra.

· Extract kinetic parameters from NMR spectra of exchanging systems.

· Demonstrate competence in basic two-dimensional NMR experiments.

8. METHODS OF EVALUATION:

Midterm exams, home-work evaluations and a comprehensive final exam will be utilized for evaluation.

9. REQUIRED AND RECOMMENDED TEXTS ANDIOR STUDY GUIDES:

Required Text: E.D. Becker, High Resolution NMR, Latest edition, Academic Press

Recommended Reference Text: J.K. Sanders and B. K. Hunter, Modem NMR Spectroscopy, Second edition, Oxford University Press (1993)

10. SUBSEQUENT COURSES: None

THE CALENDAR OF ASSIGNMENTS, ATTENDANCE AND GRADING POLICIES ARE TO BE INCLUDED IN THE COURSE SYLLABUS.